Life and nature are imperfect, uncontrollable, largely (and perhaps permanently) unknowable, that is to say: contingent. The contingency of life is a significant challenge for medicine and technology. Life sciences seem to broaden the possibilities of control to an extent that the contingency of life and nature is no longer self-evident. This very broad diagnosis raises a lot of serious questions. Is it a valid diagnosis? Are the life sciences really defying the contingency of our existence? Or we only manipulated with utopian promises? And if contingency is really being challenged, why should we worry about it? Is contingency essential for a meaningful life and way of life? This volume explores the different dimensions of how the contingency of life, and especially human life, is relevant for ethical discussions and the normative frameworks in bioethics. It explores the relevance of the notion contingency, needs and desires for moral argumentation and bioethics. The volume discusses those notions in a philosophical perspective, but pays special attention to the impact of life sciences for people with disabilities and intercultural perspectives on the bioethical debates. Additionally, the volume is a contribution to a deeper reflection on basic philosophical assumptions of bioethics.